A large aspect of humor is a reverse of expectations. The reason this is funny and the reverse is not is because the meme is the reverse of the social normative of humans. Men kill more women, men are bigger and stronger than women, men have more social power than women.
Your accusations of sexism rings hollow when you actually use logic and apply the situation to the realities of our actual societal structure.
It’s almost like memes are based on context… The reason it’s impactful is because in humans it’s rare to see women be the more powerful sex, it’s rare to see women kill men. Flipping the genders wouldn’t flip the context of the the social norms that the meme is dependent on.